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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
BRAF
All Species:
36.97
Human Site:
S446
Identified Species:
58.1
UniProt:
P15056
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15056
NP_004324.2
766
84437
S446
K
T
L
G
R
R
D
S
S
D
D
W
E
I
P
Chimpanzee
Pan troglodytes
XP_001155024
767
84561
S446
K
T
L
G
R
R
D
S
S
D
D
W
E
I
P
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532749
767
85780
S446
K
T
L
G
R
R
D
S
S
D
D
W
E
I
P
Cat
Felis silvestris
Mouse
Mus musculus
P28028
804
88899
S483
K
T
L
G
R
R
D
S
S
D
D
W
E
I
P
Rat
Rattus norvegicus
P11345
648
72910
M350
E
I
E
A
S
E
V
M
L
S
T
R
I
G
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516512
799
90020
S478
K
T
L
G
R
R
D
S
S
D
D
W
E
I
P
Chicken
Gallus gallus
Q04982
806
89347
S486
K
T
L
G
R
R
D
S
S
D
D
W
E
I
P
Frog
Xenopus laevis
P09560
638
71941
V340
W
E
I
I
A
S
E
V
M
L
S
S
R
I
G
Zebra Danio
Brachydanio rerio
NP_991307
777
86403
S456
K
T
L
G
R
R
D
S
S
D
D
W
E
I
P
Tiger Blowfish
Takifugu rubipres
NP_001032957
778
86510
S457
K
T
L
G
R
R
D
S
S
D
D
W
E
I
P
Fruit Fly
Dros. melanogaster
P11346
782
88616
S461
L
L
R
D
A
K
S
S
E
E
N
W
N
I
L
Honey Bee
Apis mellifera
XP_396892
715
80060
G409
I
L
I
G
A
R
I
G
S
G
S
F
G
T
V
Nematode Worm
Caenorhab. elegans
Q07292
813
90389
H470
P
R
P
P
Q
K
P
H
H
E
D
W
E
I
L
Sea Urchin
Strong. purpuratus
XP_781094
750
85072
S429
H
R
R
T
R
R
D
S
N
D
D
W
E
I
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q05609
821
90288
D469
V
F
D
P
A
S
D
D
M
G
F
S
M
F
H
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
92.9
N.A.
88.8
50.2
N.A.
85.7
89.8
49.3
83.5
82.9
42.8
50.6
30.7
49.3
Protein Similarity:
100
99.3
N.A.
93.4
N.A.
89.3
62.2
N.A.
86.7
90.9
61.3
87.5
87.1
57.9
65
46.6
62.6
P-Site Identity:
100
100
N.A.
100
N.A.
100
0
N.A.
100
100
6.6
100
100
20
20
26.6
66.6
P-Site Similarity:
100
100
N.A.
100
N.A.
100
6.6
N.A.
100
100
20
100
100
40
33.3
46.6
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
24
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
27
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
7
0
0
67
7
0
60
67
0
0
0
0
% D
% Glu:
7
7
7
0
0
7
7
0
7
14
0
0
67
0
0
% E
% Phe:
0
7
0
0
0
0
0
0
0
0
7
7
0
7
0
% F
% Gly:
0
0
0
60
0
0
0
7
0
14
0
0
7
7
7
% G
% His:
7
0
0
0
0
0
0
7
7
0
0
0
0
0
7
% H
% Ile:
7
7
14
7
0
0
7
0
0
0
0
0
7
80
0
% I
% Lys:
54
0
0
0
0
14
0
0
0
0
0
0
0
0
0
% K
% Leu:
7
14
54
0
0
0
0
0
7
7
0
0
0
0
14
% L
% Met:
0
0
0
0
0
0
0
7
14
0
0
0
7
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
7
0
7
0
7
0
0
% N
% Pro:
7
0
7
14
0
0
7
0
0
0
0
0
0
0
60
% P
% Gln:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
14
14
0
60
67
0
0
0
0
0
7
7
0
0
% R
% Ser:
0
0
0
0
7
14
7
67
60
7
14
14
0
0
7
% S
% Thr:
0
54
0
7
0
0
0
0
0
0
7
0
0
7
0
% T
% Val:
7
0
0
0
0
0
7
7
0
0
0
0
0
0
7
% V
% Trp:
7
0
0
0
0
0
0
0
0
0
0
74
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _